Picture of Thyrox 25 mcg Tablet 1 pot
Picture of Thyrox 25 mcg Tablet 1 pot

Thyrox 25 mcg Tablet 1 pot

Category: Prescription
SKU: BEP00144
Seller: Best Buy Pharma
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Thyrox 25 mcg Tablet 1 pot
Item code: 957478

Indications 

  • As replacement therapy in hypothyroidism of any aetiology. Replacement therapy should not be instituted in transient hypothyroidism during the recovery phase of subacute Thyroiditis.
  • For the suppression of Thyroid Stimulating Hormone (TSH) levels in the presence of goitres, nodules and after radiological and/or surgical treatment of Thyroid cancer.
  • For the suppression of the goitrogenic effects of other drugs such as Lithium.
  • As a diagnostic aid in suppression tests.

 

Pharmacology 
This tablet contains synthetic Levothyroxine (also called Thyroxine or T4) which is identical to the natural hormone T4, produced in the Thyroid gland. About 30% of T4 is converted to the much more active Triiodothyronine (T3) in peripheral tissues. TBG (Thyroxine Binding Globulin) is the major carrier of T4. This binding protects T4 from metabolism and excretion resulting in its long half-life in the circulation. Only about 0.03% of total T4 in plasma is unbound. The half-life of elimination of T4 is 6 to 7 days. In hyperthyroidism, the half-life is shortened to 3 or 4 days, whereas in hypothyroidism it may be 9 to 10 days. In conditions associated with reduced protein in plasma as in nephrosis or hepatic cirrhosis or when binding to protein is inhibited by certain drugs the half-life of T4 may be shortened. The liver is the major site of degradation of Thyroid hormones. T4 is conjugated with Glucuronic and Sulphate conjugates through the Phenolic hydroxyl group and excreted in the urine.There is an enterohepatic circulation of the Thyroid hormones, since they are liberated by hydrolysis in the intestine and reabsorbed. Because of the long half-life of T4, a steady blood level of the biologically more active T3 can be obtained from one single daily dose of Levothyroxine. Therefore, variations in the therapeutic effect are unlikely once the correct dosage has been established.

Dosage & Administration

Adult dose:
  • Initial starting dose: 25-50 mcg/day, with gradual increments in dose at 6-8 week intervals, as needed. The Levothyroxine Sodium dose is generally adjusted in 12.5-25 mcg increments until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has normalized.
  • In patients with severe hypothyroidism: Initial dose is 12.5-25 mcg/day with increases of 25 mcg/day every 2-4 weeks, accompanied by clinical and laboratory assessment,until the TSH level is normalized.
  • In patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism: Levothyroxine Sodium dose should be titrated until the patient is clinically euthyroid and the serum free - T4 level is restored to the upper half of the normal range.
  • For patients older than 50 years or for patients under 50 years of age with underlying cardiac disease: 1.7 mcg/kg/day.
Pediatric Dosage (Newborns): The recommended starting dose is 10-15 mcg/kg/day. A lower starting dose should be considered in infants at risk for cardiac failure and the dose should be increased in 4-6 weeks as needed based on clinical and laboratory response to treatment. In infants with very low (<5 mcg/dL) or undetectable serum T4 concentrations, the recommended initial starting dose is 50 mcg/day of Levothyroxine Sodium.

Pediatric Dosage (Infants and Children): In children with chronic or severe hypothyroidism, initial dose of 25 mcg/day with increments of 25 mcg every 2-4 weeks until the desired effect is achieved. Hyperactivity in an older child can be minimized if the starting dose is one-fourth of the recommended full replacement dose and the dose is then increased on a weekly basis by an amount equal to one-fourth the full recommended replacement dose until the full recommended replacement dose is reached.
  • 0-3 months: 10-15 mcg/kg/day
  • 3-6 months: 8-10 mcg/kg/day
  • 6-12 months: 6-8 mcg/kg/day
  • 1-5 years: 5-6 mcg/kg/day
  • 6-12 years: 4-5 mcg/kg/day
  • >12 years but growth and puberty incomplete: 2-3 mcg/kg/day
  • Growth and puberty complete: 1.7 mcg/kg/day.
The dose should be adjusted based on clinical response and laboratory parameters.

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Storage Conditions
Store below 30°C and dry place, protect from light. Keep out of the reach of children.

Side Effects
Adverse reactions associated with Thyrox therapy are primarily those of hyperthyroidism due to therapeutic overdose. They include the following:

  • General: Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating;
  • Central nervous system: Headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia.
  • Musculoskeletal: Tremors, muscle weakness.
  • Cardiovascular: Palpitations, tachycardia, arrhythmias, increased pulse and blood pressure
  • Respiratory: Dyspnea.
  • Gastrointestinal: Diarrhea, vomiting, abdominal cramps.
  • Dermatologic: Hair loss, flushing.

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